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which of the following is most likely to occur due to the damage of thymus in a child reduction in RCB count in blood increase of antibody mediated immunity decreased count of WBC and platelets in blood loss of cell mediated immunity

which of the following is most likely to occur due to the damage of thymus in a child
  1. reduction in RCB count in blood
  2. increase of antibody mediated immunity
  3. decreased count of WBC and platelets in blood
  4. loss of cell mediated immunity

Grade:12

2 Answers

Gaurav
askIITians Faculty 164 Points
9 years ago
Hello Student
Correct answer is 4) Loss of Cell Mediated Immunity
Thymus secreted peptide hormones named thymosine. These stimulated development and differentiation of T- lymphocytes.
They Provide humoral immunity and cell – mediated immunity,
Raheema Javed
156 Points
9 years ago
Due to the damage of thymus in a child loss of cell mediated immunity is most likely to occur because T cells (type of immune cell) which are responsible for cell mediated immunity mature in the thymus.
The thymus is a specialized organ of the immune system. Within the thymus, T-cells mature.T cells are critical to the adaptive immune system, where they adapt specifically to foreign invaders. Each T cell attacks a specific foreign substance which it identifies with its receptor. T cells have receptors which are generated by randomly shuffling gene segments. Each T cell attacks a different antigen. T cells that attack the body's own proteins are eliminated in the thymus. Thymic epithelial cells express major proteins from elsewhere in the body. First, T cells undergo "Positive Selection" whereby the cell comes in contact with self-MHC expressed by thymic epithelial cells; those with no interaction are destroyed. Second, the T cell undergoes "Negative Selection" by interacting with thymic dendritic cell whereby T cells with high affinity interaction are eliminated through apoptosis (to avoid autoimmunity), and those with intermediate affinity survive.

Histologically, each lobe of the thymus can be divided into a central medulla and a peripheral cortex which is surrounded by an outer capsule. The cortex and medulla play different roles in the development of T-cells. Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow resident hematopoietic stem cells). Developing T-cells are referred to as thymocytes and are of hematopoietic origin. Stromal cells include thymic cortical epithelial cells, thymic medullary epithelial cells, and dendritic cells.

The thymus provides an inductive environment for development of T-lymphocytes from hematopoietic progenitor cells. In addition, thymic stromal cells allow for the selection of a functional and self-tolerant T-cell repertoire. Therefore, one of the most important roles of the thymus is the induction of central tolerance.

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