which of the following combination of drugs has a dramatic rapid increse in sedative effect

1. alcohol+antihistamines
2. alcohol+benzodiazepines
3. alcohol+aspirin
4. amphetamine+insulin

The correct answer is (2) alcohol + benzodiazepines

Benzodiazepines, or “benzos”, are a family of sedatives or minor tranquilizers that are designed to treat insomnia, sleep deprivation, and anxiety. When these drugs are mixed with alcohol, they can intensely magnify alcohol’s depressive effects and place users in serious physical and emotional jeopardy. Mixing alcohol and benzos can impair judgment, significantly decrease mobility or control over one’s own movements, and dramatically depress the central nervous system.