What are the limitations of Hoffman amonolysis of alkyl or aryl halides for preparations of alkyl or aryl amines?

Question

Suraj Prasad · Answer

Halo alkanes react with alcoholic NH3to form amine . But when halo alkane is in excess, the reaction doesnot stop rather continues till tertiary amine is formed. This continuous ammonolysis is called Hoffman’s ammonolysis.
Limitation :
1) It yields mixture of primary,secondary , tertiary and also a quaternary ammonium salt.

2) Aromatic amines could not be prepared since aryl halides are much less reactive towards nucleophilic substitution reactions.

SHAIK HAFEEZUL KAREEM · Answer

Halo alkanes react with alcoholic NH3to form amine . But when halo alkane is in excess, the reaction doesnot stop rather continues till tertiary amine is formed. This continuous ammonolysis is called Hoffman’s ammonolysis.
Limitation :
1) It yields mixture of primary,secondary , tertiary and also a quaternary ammonium salt.

2) Aromatic amines could not be prepared since aryl halides are much less reactive towards nucleophilic substitution reactions.

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What are the limitations of Hoffman amonolysis of alkyl or aryl halides for preparations of alkyl or aryl amines?

What are the limitations of Hoffman amonolysis of alkyl or aryl halides for preparations of alkyl or aryl amines?

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