What is Myxodema ?

Myxedema (British English: Myxoedema) is a term used synonymously with severe hypothyroidism. It is also used to describe a dermatological change that can occur in hypothyroidism, and some forms of hyperthyroidism. This article discusses the dermatological changes.

In this context, myxoedema refers to mucopolysaccharides deposition in the dermis. This results in swelling of the affected area. One manifestation of myxoedema occurring in the lower limb is pretibial myxedema, a hallmark of Graves disease. Myxoedema can occur in Hashimoto's thyroiditis and other long-standing forms of hypothyroidism, as well as Graves disease, an autoimmune form of hyperthyroidism.

Myxedema is a term used synonymously with severe hypothyroidism. It is also used to describe a dermatological change that can occur in hypothyroidism, and some forms of hyperthyroidism.
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Myxedema is a term used synonymously with severe hypothyroidism. It is also used to describe a dermatological change that can occur in hypothyroidism, and some forms of hyperthyroidism.
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Myxodema is a term used synonymously with severe hypothyroidism. It is also used to describe a dermatological change that can occur in hypothyroidism, and some forms of hyperthyroidism.
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Myxedema is a condition marked by thickening and swelling of the skin caused by insufficient production of thyroid hormones by the thyroid gland. The function of thyroid hormones is to regulate your metabolism. Myxedema is associated with other symptoms of underactive thyroid, also called hypothyroidism, including lethargy, weight gain, fatigue, depression, and cold sensitivity, among others.
Myxedema is usually part of a larger group of symptoms associated with hypothyroidism.
At times any of these symptoms can be severe and include:

Brittle hair or fingernails
Constipation
Decreased sweating
Depression
Dry or pale skin
Fatigue
Malaise or lethargy
Musculoskeletal pain
Sensitivity to cold
Thickening of the skin
Weakness (loss of strength)
Weight gain

Myxedema is caused by an accumulation of tissue products, such as glycosaminoglycans, in the skin. Myxedema is almost always a result of hypothyroidism. Specific causes of hypothyroidism that can lead to myxedema include Hashimoto’s thyroiditis, thyroidectomy (surgical removal of the thyroid), and Graves’ disease.