Grade 12th passPhysical Chemistry
what is the difference between partition and distribution coefficient? Explain with examples.
what is the difference between partition and distribution coefficient? Explain with examples.
1 Answer
Arun
Partition coefficient
In drug discovery and development, lipophilicity is usually expressed by the partition between water and octan-1-ol.
In drug discovery and development, lipophilicity is usually expressed by the partition between water and octan-1-ol.
It is usual to give the logP value (the logarithm to the base 10 of the partition coefficient). Sometimes a value is calculated - from knowledge of the molecular structure - rather that determined experimentally. These values are denoted by using clogP.
The drug molecule must be unionised in aqueous solution.
The drug molecule must be unionised in aqueous solution.
Distribution Coefficient
The distribution constant is pH dependent and the term logD is used to reflect the pH dependent lipophilicity of a drug.
The lower the pH of an aqueous solution, the further to the left is the position of equilibrium, i.e. increasing [drug molecule]water and decreasing [drug ion]water.
Below a certain pH, [drug ion]water becomes close to zero.
The lower the pH of an aqueous solution, the further to the left is the position of equilibrium, i.e. increasing [drug molecule]water and decreasing [drug ion]water.
Below a certain pH, [drug ion]water becomes close to zero.
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