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Give the reaction only to prepare Aspirine from Salicylic Acid.?

Give the reaction only to prepare Aspirine from Salicylic Acid.?

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1 Answers

Sunil Kumar FP
askIITians Faculty 183 Points
8 years ago
Salicylic acid is a natural analgesic present in the leaves and bark of certain plants. It is generally unsuitable for internal use, since it is a strong gastric irritant and can cause internal bleeding.
Acetylsalicylic acid is hydrolyzed to salicylic acid (SA). The SA is reacted with NaOH to form sodium salicylate. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH3). This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Small amounts of sulfuric acid (and occasionally phosphoric acid) are almost always used as a catalyst

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