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Physical Chemistry

Give the reaction only to prepare Aspirine from Salicylic Acid.?

Profile image of puja kumari
12 Years agoGrade
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Profile image of Sunil Kumar FP
11 Years ago
Salicylic acid is a natural analgesic present in the leaves and bark of certain plants. It is generally unsuitable for internal use, since it is a strong gastric irritant and can cause internal bleeding.
Acetylsalicylic acid is hydrolyzed to salicylic acid (SA). The SA is reacted with NaOH to form sodium salicylate. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH3). This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Small amounts of sulfuric acid (and occasionally phosphoric acid) are almost always used as a catalyst