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Oxidation of Primary Alcohols and Aldehydes
Oxidation of Alkyl Benzenes
Grignard Synthesis of Carboxylic Acid
Oxidation of Alkenes
Hydrolysis of Nitriles
Hydrolysis of Trihalogen Derivatives
Oxidation of Methyl Ketone
Koch Reaction
Heating Gem Dicarboxylic Acids
Hydrolysis of acyl halides and anhydrides
Hydrolysis of esters
Oxidation is a direct method most commonly used for preparation of carboxylic acids. Direct oxidation of alcohols, ketons. aldehydes, alkenes and alkyl benzene results in formation of carboxylic acids
Primary alcohols on oxidation give aldehydes, the reaction does not stop here and the oxidation continues to give carboxylic acids as final product.
Primary alcohol Aldehyde Carboxylic Acid
or
Example:
2-Metyl-1-butanol 2-Metyl-1-butanoic acid
Strong oxidation of alkyl benzenes also result in formation of carboxylic acids
Example
?Grignard synthesis has the advantage of increasing the length of carbon chain and thus it is useful for extending the range of available materials.
CO2(g) is bubbled into ether solution of grignard reagent which results in addition of grignard reagent to the C=O bond to form magnesium slats of the carboxylica cids from which carboxylic acids are produced by treatement with mineral acids
This method is useful for converting alkyl halides into corresponding carboxylic acids having one carbon atom more than that present in alkyl halides (ascending the series)
Strong oxidation of alkenes results in formation of carboxylic acids. Alkenes can be oxidized to carboxylic acids with hot alkaline KMnO4
2-Butene Ethanoic Acid
?Just like grignard synthesis , nitrile synthesis also increases the length of carbon chain. Aliphatic nitriles are prepared by treatment of alkyl halides with sodium cyanide in a solvent that will dissolve both reactants. In dimethyl sulfoxide (DMSO), reaction occurs rapidly and exothermically at room temperature. The resulting nitrile is then hydrolysed to the acid by boiling with aqueous alkali or acid.
This synthetic method is generally limited to the use of primary alkyl halides. Aryl halides (except for those with ortho and para nitro groups) do not react with sodium cyanide.
Trihalogen derivatives in which the three halogen atoms are all attached to the same carbon atom yields carboxylic acid on hydrolysi
CH3CCl3 + KOH → CH3CO2 + H2O
Methyl ketone can be converted to carboxylic acids via the haloform reaction.
A recent method for manufacturing fatty acids is to heat an olefin with carbon monoxide and steam under pressure at 300-400° C in the presence of a catalyst, e.g. phosphoric acid.
CH2 = CH2 + CO + H2O → CH3 – CH2 – COOH
The most convenient laboratory preparation for formic acid is to heat glycerol with oxalic acid at 100 – 110° C.
Acid chlorides on hydrolysis give carboxylate ions which on acidification provide corresponding carboxylic acids.
Acid Anhydrides on the other hand give corresponding acid on hydrolysis.
Acid Chloride Carboxylic acid
Benzoic anhydride Benzoic Acid
Acidic hydrolysis of esters gives directly carboxylic acids while basic hydrolysis gives carboxylates, which on acidification give? carboxylic acids
Ethyl Benzoate Benzoic Acid
Ethyl butanoate Butanoic Acid
You can also refer to Organic Chemistry Revision Notes and IIT JEE Chemistry Syllabus
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