wobble hypothesis was given by R.W. holley M. nirenberg H.G. khorana F.H.C. crick

wobble hypothesis was given by
  1. R.W. holley
  2. M. nirenberg
  3. H.G. khorana
  4. F.H.C. crick

Grade:12th pass

1 Answers

Apoorva Arora IIT Roorkee
askIITians Faculty 181 Points
8 years ago
In 1966, Francis Crick proposed the Wobble hypothesis. He suggested that while the interaction between the codon in the mRNA and the anticodon in the tRNA needed to be exact in two of the three nucleotide positions, this did not have to be so in the third position. He proposed that non-standard base-pairing might occur between the nucleotide base in the 5' position of the anticodon and the 3' position of the codon.

This hypothesis not only accounts for the number of tRNAs that are observed, it also accounts for the degeneracy that is observed in the Genetic Code. The degenerate base is that in the wobble position.

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