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When hydrogen ion combines with Hb in erythrocytes it forms HHb. What does it role

When hydrogen ion combines with Hb in erythrocytes it forms HHb. What does it role

Grade:12th pass

2 Answers

Umakant biswal
5359 Points
4 years ago
@ jaina 
the main function is  to form the oxyhaemoglobin , this HHB complex is gng to combine with oxygen to form HHBO2 , and that will for oxyhaemoglobin . 
these oxyhaemoglobin are nessasary for the transport of oxygen with blood  '
dolly bhatia
200 Points
4 years ago
When hydrogen ion combines with Hb in erythrocytes, it forms HHb. What is its role?
Gas exchange happens both in the lungs, referred to as external respiration and the tissues, referred to as internal respiration. Key player for this process is haemoglobin (Hb), a respiratory pigment in red blood cells. Haemoglobin can exist in various forms, depending on what it is bound to:
If it is carrying H+ ions, it is called reduced hemoglobin(HHb).
When oxygen goes into the blood, it will kick H+ off the HHb by attaching to hemoglobin to form HbO2.
Lungs are cooler and have a higher pH, which causes hemoglobin to have a shape that is perfect to bind oxygen.
HHb -àHb and H+
The hydrogen ion does not accumulate because as soon as it is released from HHb, it combines with HCO3- to form carbonic acid, which then changes into carbon dioxide, which can now diffuse out of blood into the alveoli.    
H+   + HCO3-    à      H2CO3     à     H2O  +  CO2
This reaction is catalyzed by enzyme  carbonic anhydrase. This reaction is later reversed by same enzyme as blood enters tissues.
Once oxyhemoglobin arrives in capillaries in the tissues, the oxygen is released. Now, the tissues have a higher temperature and a lower pH. Hemoglobin shifts its shape and no longer binds the oxygen as tightly.
HbO2 à     Hb  +  O2  
Most of the hydrogen ions are now picked up by deoxyhemoglobin to form reduced hemoglobin (HHb).
H+  + Hb à HHb
Because partial pressure of oxygen is now higher in the blood than in the tissues, it diffuses out of the blood and into the tissues.
SO2 is the percentage of functional Hb that is saturated with oxygen. It is calculated as concentration of O2Hb divided by functional Hb, which is sum of oxyhemoglobin (O2Hb) and deoxygenated Hb(HHb).

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