Sporozite is the infective stage of malarial parasite.Transmission of malaria occurs through a vector, the mosquito, that ingests gametocytes the sexual form of the parasite when feeding on an infected human. Gametocytes, which are both male and female, mate within the gut of the mosquito and undergo meiosis and then migrate through the midgut wall of the mosquito and form an oocyst, within which thousands of sporozoites develop. These are then injected into a human during the next blood meal(s), where they rapidly make their way to the liver and infect hepatocytes and begin asexually (mitotically) replicating. After a period of ca. 6 15 days, the liver schizonts rupture, releasing thousands of merozoites into the blood where they invade red blood cells. Over the next ca. 48 h, the parasite begins replicating mitotically, progressing through a set of stages (ring, trophozoite and schizont), and produces an average of 16 new daughter merozoites per schizont. The schizonts then burst in near synchrony with other parasites, producing the characteristic fever cycle that embodies the clinical manifestations of the disease. With each replication, some of the merozoites, instead of producing new merozoites, develop into gametocytes, which can then infect susceptible mosquitoes, bringing the transmission cycle full circle
						

							
 THE INFECTIVE STATE OF MALARIA IS SPOROZOITE . THE SEXUAL STAGE OF PLASMODIUM TAKES PLACE IN FEMALE ANOPHELES MOSQUITO WHERE AS THE ASEXUAL STAGE OCCURS IN MAN . WHEN A FEMALE MOSQUITO  BITES AN INFECTED PERSON , THESE PARASITES ENTER THE MOSQUITO BODY AND UNDERGO FURTHER DEVELOPMENT IN THE BODY OF THE MOSQUITO TO FORM SPOROZOITE  THAT ARE  STORED IN THE SALAIVARY GLAND  OF THE MOSQUITO . WHEN THESE MOSQUITOES BITE A HEALTHY PERSON , THE SPOROZOITE ARE INTRODUCED INTO HIS BODY  THEY MULTIPLY WITHIN THE LIVER CELLS FIRST AND ENTER  THE RBC OF MAN CAUSING RUPTURE OF THE RBC . THIS RESULTS IN  THE RELEASE OF TOXIC SUBSTANCE  CALLED HAEMOZOIN WHICH IS RESPONSIBLE FOR THE CHILLS AND HIGH FEVER