in DNA model of watson and crick the major grooves represent one the following sites.

1. binding of histone protiens
2. binding of acidic protiens
3. binding of rna molecules
4. binding of glycoprotiens

Hello Student
Correct answer is 2) Binding of acidic proteins
The major groove is 22Å wide and the other the minor grove is 12Å wide. the narrowness of minor groove means thet the edged of the bases are more accesible in the major grooves.

The correct answer is (2) binding of acidic proteins

The width of the major groove means that the edges of the bases are more accessible in the major groove than in the minor groove. As a result, proteins such as transcription factors that can bind to specific sequences in double-stranded DNA usually make contact with the sides of the bases exposed in the major groove.