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Grade: 12
        
For its activity, carboxypeptidase requires Zinc.Why?
2 years ago

Answers : (1)

RAHUL ROHILLA
askIITians Faculty
873 Points
							As the protein substrate binds to carboxypeptidase, the active site closes in around it. Hydrolysis of the peptide bond is most likely to occur if the terminal residue has an aromatic or bulky hydrocarbon side chain. A zinc ion (Zn2+) is tightly bound near the active site and assists in catalysis. Three hydrogen bonding and electrostatic interactions are critical for the enzyme to recognize the terminal amino acid in the peptide chain. The intermediate is stabilized by interactions with Zn2+and the carboxypeptidase molecule. The last step is a proton transfer and cleavage of the peptide bond. This entire process requires considerable mobility of the carboxypeptidase A protein itself.
						
2 years ago
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