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Among the given compounds, the most susceptible to nucleophilicattack at the carbonyl group is (a) MeCOCI (b) MeCHO (c) MeCOOMe (d) MeCOOCOMe

Among the given compounds, the most susceptible to nucleophilicattack at the carbonyl group is
(a) MeCOCI
(b) MeCHO
(c) MeCOOMe
(d) MeCOOCOMe

Grade:upto college level

1 Answers

Navjyot Kalra
askIITians Faculty 654 Points
9 years ago
Hello Student,
Please find the answer to your question
(a). Greater the ease of leaving group, easier will be the nucleophilic substitution. Further, weaker the base, the better is its leaving characteristic which lies in the following order.
Cl− > −OCOCH3 > −OCH3 > H−
Very weak base strongest base
Hence CH3COCl will be most reactive for nucleophilic substitution at acyl carbon.
Thanks
Navjyot Kalra
askIITians Faculty

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