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Among the given compounds, the most susceptible to nucleophilicattack at the carbonyl group is (a) MeCOCI (b) MeCHO (c) MeCOOMe (d) MeCOOCOMe

Among the given compounds, the most susceptible to nucleophilicattack at the carbonyl group is
(a) MeCOCI
(b) MeCHO
(c) MeCOOMe
(d) MeCOOCOMe

Grade:11

1 Answers

Kevin Nash
askIITians Faculty 332 Points
7 years ago

(a). Greater the ease of leaving group, easier will be the nucleophilic substitution. Further, weaker the base, the better is its leaving characteristic which lies in the following order.

Cl- > -OCOCH3 > -OCH3 > H-

Very weak base strongest base

Hence CH3COCl will be most reactive for nucleophilic substitution at acyl carbon.

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