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Define Williamson's synthesis?

Prem kumar , 12 Years ago
Grade Upto college level
anser 1 Answers
Akshay Meena

This method is suitable for the preparation of a wide variety of unsymmetric ethers. The nucleophilic substitution of halides with alkoxides leads to the desired products.

http://www.organic-chemistry.org/namedreactions/Willia1.gif

If the halides are sterically demanding and there are accessible protons in the β-position, the alkoxide will act as a base, and side products derived from elimination are isolated instead.

http://www.organic-chemistry.org/namedreactions/Willia2.gif

 

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Akshay Meena, 
askIITians Faculty
M.Tech, IIT Kharagpur
Last Activity: 12 Years ago
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