Flag Organic Chemistry> Amine synthesis...
question mark

Explain Gabriel phtalimide synthesis?

deb sss saha , 15 Years ago
Grade 11
anser 1 Answers
Badiuddin askIITians.ismu Expert

Last Activity: 15 Years ago

Hi deb saha

Gabriel Synthesis

Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.


Mechanism of the Gabriel Synthesis

Cleavage:


Regards

Badiuddin

star
LIVE ONLINE CLASSES

Prepraring for the competition made easy just by live online class.

tv

Full Live Access

material

Study Material

removal

Live Doubts Solving

assignment

Daily Class Assignments