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Grade: 11
        

Explain Gabriel phtalimide synthesis?

10 years ago

Answers : (1)

Badiuddin askIITians.ismu Expert
147 Points
							

Hi deb saha

Gabriel Synthesis

Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.


Mechanism of the Gabriel Synthesis

Cleavage:


Regards

Badiuddin

10 years ago
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