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sir /madam can u plz tel me why dont we use toluene as a solvent in Grignard reaction with the mechanism behind it................................ tnq u

sir /madam


can u plz tel me why dont we use toluene as a solvent in Grignard reaction with the mechanism behind it................................


tnq u

Grade:

1 Answers

Aman Bansal
592 Points
9 years ago

Dear Student,

Grignard Reaction
Grignard Reagents

The Grignard Reaction is the addition of an organomagnesium halide (Grignard reagent) to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. The reaction with formaldehyde leads to a primary alcohol.

Grignard Reagents are also used in the following important reactions: The addition of an excess of a Grignard reagent to an ester or lactone gives a tertiary alcohol in which two alkyl groups are the same, and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone via a metalloimine intermediate. (Some more reactions are depicted below)


Mechanism of the Grignard Reaction

While the reaction is generally thought to proceed through a nucleophilic addition mechanism, sterically hindered substrates may react according to an SET (single electron transfer) mechanism:

With sterically hindered ketones the following side products are received:

The Grignard reagent can act as base, with deprotonation yielding an enolate intermediate. After work up, the starting ketone is recovered.

A reduction can also take place, in which a hydride is delivered from the β-carbon of the Grignard reagent to the carbonyl carbon via a cyclic six-membered transition state.

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