Hi
Molecular geometry or molecular structure is the three-dimensional arrangement of the atoms that constitute a molecule. It determines several properties of a substance including its reactivity, polarity, phase of matter, color, magnetism, and biological activity.
Isomers are types of molecules that share a chemical formula but have different geometries, resulting in very different properties:

    
A pure substance is composed of only one type of isomer of a molecule (all have the same geometrical structure). 


    
Structural isomers have the same chemical formula but different physical arrangements, often forming alternate molecular geometries with very different properties. The atoms are not bonded (connected) together in the same orders. 
    

        
Functional isomers are special kinds of structural isomers, where certain groups of atoms exhibit a special kind of behavior, such as an ether or an alcohol. 
    
    


    
Stereoisomers may have many similar physicochemical properties (melting point, boiling point) and at the same time very different biochemical activities. This is because they exhibit a handedness that is commonly found in living systems. One manifestation of this chirality or handedness is that they have the ability to rotate polarized light in different directions. 


    
Protein folding concerns the complex geometries and different isomers that proteins can take.  

Stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but which differ only in the three-dimensional orientations of their atoms in space
						

							
Spatial orientation is arrangement of atoms or electrons in 3 dimension or space.It provides correct information about orientation of atoms and electrons  which can't be observed in 2 dimension.Magnetic orbital quantum number gives information about spatial orientation of the orbital with respect to standard set of co-ordinate axis.