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Why are cimetidine and ranitidine better antacids than sodium hydrogencarbonate or magnesium or aluminium hydroxide?

Why are cimetidine and ranitidine better antacids than sodium hydrogencarbonate or magnesium or aluminium hydroxide?

Grade:12th pass

1 Answers

Pawan Prajapati
askIITians Faculty 60787 Points
3 years ago
If excess of NaHCO3 or Mg(OH)2 or Al(OH)3 is used, it makes the stomach alkaline and thus triggers the release of even more HCl which may cause ulcer in the stomach. In contrast, cimetidine and ranitidine prevent the interaction of histamine with the receptor cells in the stomach wall and thus release of HCl will be less as histamine stimulates the secretion of acid.

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