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Allostery is a property not limited to enzymes. The basic principles of allostery are also well illustrated by the oxygen-transport protein hemoglobin (Section 7.2). The binding of oxygen to hemoglobin isolated from red blood cells displays marked sigmoidal behavior (similar to that observed for the activity of ATCase, as a function of substrate concentration), which is indicative of cooperation between subunit. What is the physiological significance of the cooperative binding of oxygen by hemoglobin? Oxygen must be transported in the blood from the lungs, where the partial pressure of oxygen (pO2) is relatively high (approximately 100 torr), to the tissues, where the partial pressure of oxygen is much lower (typically 20 torr). Let us consider how the cooperative behavior represented by the sigmoidal curve leads to efficient oxygen transport. In the lungs, hemoglobin becomes nearly saturated with oxygen such that 98% of the oxygen-binding sites are occupied. When hemoglobin moves to the tissues, the saturation level drops to 32%. Thus, a total of 98 - 32 = 66% of the potential oxygen-binding sites contribute to oxygen transport. In comparison, for a hypothetical noncooperative transport protein, the most oxygen that can be transported from a region in which pO2 is 100 torr to one in which it is 20 torr is 63 - 25 = 38% Thus, the cooperative binding of oxygen by hemoglobin enables it to deliver 1.7 times as much oxygen as it would if the sites were independent. The homotropic regulation of hemoglobin by its ligand oxygen dramatically increases its physiological oxygen-carrying capacity.
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