“Is there any difference between karyotype and a genome, either yes or no explain with solid reason?”

Yes
Karyotype is the representation of all the chromosome pairs. It hels you study the chromosomal abnormalities like that of Trisomy, Monosomy etc. term karyotye is generally in reference to chromosomes
Genome- it is the complete set of genes in haploid set of chromosome. Term genome is in reference to all the genes.

Note: Genes are carried on chromosomes