How is 'Coronary Artery Disease’ related to a dysfunctioning glycolysis?

How is 'Coronary Artery Disease’ related to a dysfunctioning glycolysis?

Grade:12th pass

2 Answers

Aabid Hussain
askIITians Faculty 576 Points
8 years ago
Hi Orooba,

Thank you for asking
Coronary Artry/Heart Disease (CAD/CHD) is normally related with numerous metabolic disturbances including glycolysis. Reason may be numerous and among many symptoms of glycolysis, hyperuricemia (high level of uric acid in blood) is one on them due to dysfunctioning of Glyceraldehyde-3-phosphate dehydrogenase enzyme.

The increased level of uric acid in blood leads to hypertonic blood and this will cause the coronary artries cells to loose their water content and hence the pathogenic effect.

Other possibilities are deficiency in ATP (Some of ATP generated during glycolysis) which leads to pumping dysfunction of heart. These reasons are still under the screen of research.

Kindly let me know if you are satisfied or need further explanation.
Orooba Asim
12 Points
8 years ago
Okay, so just like this a dysfunctioning glycolysis can be associated with other diseases as well right and not just CAD? Thank you very much I understood! 

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