Chromosomes are made up of

A) DNA only

B) Protein only

C) DNA and protein

D) RNA only

Chromosomes are present as thread like structures packed inside the nucleus of a plant cell or animal cell. Each chromosome is made up of protein and a single molecule of DNA (deoxyribonucleic acid).
RNA is synthesized in nucleus but found mainly in the cytoplasm of the cell. Hence, chromosomes are not made of RNA.
Therefore, chromosomes are made of DNA and protein.