11 grade chemistry others
Explain Hoffmann's exhaustive alkylation with examples.
Explain Hoffmann's exhaustive alkylation with examples.
1 Answer
Askiitians Tutor Team
Hofmann's exhaustive alkylation, also known as the Hofmann degradation or Hofmann rearrangement, is a chemical reaction used to convert primary amides (RC(O)NH2) into primary amines (RNH2) with one fewer carbon atom in the alkyl chain. The reaction involves the conversion of the primary amide into an isocyanate intermediate, which is then hydrolyzed to yield the primary amine. This process is widely used in organic chemistry for the synthesis of primary amines.
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