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deb sss saha Grade:
        

Explain Gabriel phtalimide synthesis?

7 years ago

Answers : (1)

Badiuddin askIITians.ismu Expert
147 Points
										

Hi deb saha


Gabriel Synthesis



Potassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.




Mechanism of the Gabriel Synthesis




Cleavage:







Regards


Badiuddin

7 years ago
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